Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche

Abstract The cellular organization of gastrointestinal crypts is orchestrated by different cells of the stromal niche but available in vitro models fail to fully recapitulate the interplay between epithelium and stroma.Here, we establish a colon assembloid system comprising the epithelium and diverse stromal cell subtypes.These assembloids recapitu

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Observational study on dry period length and its associations with milk production, culling risk, and fertility in Italian dairy farms

ABSTRACT: From an initial data set involving 84,189 lactations, this research evaluated the relationship between dry period length (DPL) and milk production, culling risk, and fertility.The data set included a total of 48,297 multiparous cow lactation records, with a calving event occurring in 2019 and 2020, belonging to 62 Italian herds with at le

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The impact of lifestyle Physical Activity Counselling in IN-PATients with major depressive disorders on physical activity, cardiorespiratory fitness, depression, and cardiovascular health risk markers: study protocol for a randomized controlled trial

Abstract Background Major depressive disorder (MDD) is a widespread and burdensome psychiatric issue.Physical activity counselling may increase lifestyle physical activity and cardiorespiratory fitness in this specific and particularly vulnerable population, which often suffers from both mental and physical health problems.Therefore, this study wil

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